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Symptoms – Blisters or Vesicles

Atopic dermatitis (AD) causes changes on the visible surface of the skin, as well as the deeper layers of the skin. AD often causes dry, scaly patches of inflammation, and most frequently begins in childhood, although some cases persist or begin in adulthood. In addition to the dry, scaly patches, some people experience blisters or vesicles with AD. (Vesicles are fluid-filled bumps.)1

How atopic dermatitis causes blisters and vesicles

The body naturally forms blisters when the skin has been damaged by friction, such as rubbing, or due to exposure to heat, cold, or a chemical. AD is caused by a combination of genetic, immunologic, and environmental factors. In people with AD, there is a decrease or lack of filaggrin in the skin. Filaggrin is a protein that plays a key role in the structure and formation of the corneal layer of the skin. The lack of filaggrin has been traced back to genetic mutations in the FLG gene. Not having enough filaggrin in the skin layers creates a damaged skin barrier, leading to a reduced ability to maintain the skin’s natural amount of water, as well as the sores and rash of AD.

The damaged skin barrier may also allow for the entry of airborne allergens to enter the skin, which could lead to an inflammatory response by the immune system. Another theory suggests that the normal pH of the skin barrier may be affected by filaggrin defects, which could lead to the overgrowth of bacteria. This could then trigger the immune system to create inflammatory skin lesions. There is also emerging evidence that the dysfunction in the immune system in patients with eczema not only causes disease but also decreases the amount of functional filaggrin. Immune system dysfunction also creates an increase in inflammation in people with AD.2,3

Blisters and itching

In addition, the intense itch caused by AD leads to repeated scratching and rubbing of the area, which can cause blisters or vesicles to form. The exact disease processes that cause itch in AD are not completely understood, but doctors know that the “itch-scratch cycle” (the skin feels itchy, which leads to scratching, which then causes the skin to feel even more itchy) perpetuates the disease. The itch appears to start before the plaques or inflammation. Research has uncovered that itch in AD is related to the close relationship between the nervous system and the skin. The nerves in the skin send an “itch” message to the brain through chemical messengers called cytokines. Researchers are studying the different mechanisms related to itch, including how people with AD may have skin sensitivity that causes other sensations, such as heat or pain, to be perceived as itch.4,5

Blisters and infections

Blisters can also form in people with AD who have a viral infection, such as an infection of herpes simplex virus (HSV). Due to the dysfunction in the immune system, people with AD are at an increased risk of serious viral infections of the skin. Herpes simplex virus infection is fairly common, and because it is contagious, direct contact with someone who has active cold sores should be avoided. Because of the skin barrier damage in people with AD, these viruses have the potential to spread and may become life-threatening, and prompt medical attention and treatment are required.6,7

Treating blisters and vesicles of atopic dermatitis

People with AD are treated with a combination of good skin care, including regular use of moisturizers, and different therapies. Moisturizers are one of the basic necessities for people with AD, regardless of the severity of their disease. Moisturizers help repair the damaged skin barrier caused by AD and help retain needed moisture in the skin.

Medications used in the treatment of AD include:

Wet-wrap therapy, with or without a topical corticosteroid, is another technique that can help weepy sores from AD. Wet- wrap therapy involves applying the medication (if using) and wrapping the affected area in a layer of wetted gauze, cotton, or bandages, followed by a layer of dry bandages. Wet-wrap therapy helps improve the moisture of the affected skin, improves the penetration of the topical medicine, and provides a physical barrier against scratching.8

Other symptoms of atopic dermatitis

In addition to blisters and vesicles, AD can cause a rash, scaly patches, itch, bumps or papules, blisters, and a change in skin color. Some people also experience eye symptoms or cracks behind the ears. Over time, the areas of skin affected by AD may become thickened.

Emily Downward | June 2017
  1. MedlinePlus, U.S. National Library of Medicine. Accessed online on 4/19/17 at
  2. Tollefson MM, Bruckner AL. Atopic dermatitis: skin-directed management. Am Acad Pediatrics. 2014 Dec;134(6):e1735-1744. doi: 10.1542/peds.2014-2812.
  3. Brunner PM et al. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol. 2017 Apr;139(4S):S65-S76.
  4. Yarbrough KB, Neuhaus KJ, Simpson EL. The effects of treatment on itch in atopic dermatitis. Dermatol Ther. 2013;26:110-119.
  5. Murota H, Katayama I. Exacerbating factors of itch in atopic dermatitis. Allergology International. 2017. 66:8-13.
  6. Leung, DYM. Infection in atopic dermatitis. Curr Opin Pediatr. 2003;15:399-404.
  7. Peterson JD, Chan LS. A comprehensive management guide for atopic dermatitis. Dermatology Nursing. 2006;18(6):531-542. Accessed online on 4/5/17 at
  8. Eichenfield LF, Tom WL, Chamilin SL, et al. Guidelines of care for the management of atopic dermatitis. Journal of the American Academy of Dermatology. 2014;70:338- 351.