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7 Strange and Fascinating Eczema Symptoms

If I asked you to name three symptoms of eczema, you’d probably say itchy, dry, and um, flaky skin?” Well obviously, because these are literally the principal features of eczema itself.

Today will be different. Having lived with eczema for 15+ years, I have collected a number of symptoms which are both strange, and fascinating, that I’d like to share with you. See if you identify with any of these!

1. Sign of Hertoghe (Queen Anne’s sign)

Do you have partial thinning or loss of hair in the outer third of your eyebrows?

The Sign of Hertoghe (which I still cannot pronounce), is a common sign of underactive thyroid and atopic dermatitis. It’s named after thyroid function researcher, Eugene Hertoghe; it’s also associated with Anne of Denmark in the 17th century, but this seems to be disputed.

This is a highly specific location and confirms with eczema patients I’ve met in person. Myself included. This happens to me only after adolescence. In fact, I predict it is a symptom for those entering adulthood. It brings no harm and occurs from an unconscious reflex to remove hair.

2. Dennie–Morgan Fold (aka. Infraorbital Fold, Dennie’s Sign)

Do you have panda eyes? Are the space below your eyelids darkened?

This results from an edema, which means abnormal circulation of fluid, in people with atopic dermatitis. In fact, this symptom is accurate enough to be adopted as a diagnostic criterion for allergy with above 75% accuracy.1 However, the mechanism behind is unknown.

The Dennie-Morgan fold should not be confused with allergic shiners, which are black eyes (or purple-gray discoloration), resulting from blood accumulation due to nasal congestion.

3. Atopic March

Apart from atopic dermatitis (atopic eczema), do you also have food allergy, allergic rhinitis (hay fever) and asthma?

These conditions are all inextricably connected through genetic risk factors. You might experience them one at a time, or simultaneously at different life stages. Personally, I used to sneeze about 30 times each morning in primary to middle school. Food allergy was always present, but I never developed asthma.

Unfortunately, the atopic march is manifested due to our genetics.

According to Dr. Manuel Ferreira of the QIMR Berghofer Medical Research Institute, “… these genes influence the risk of asthma, hay fever and eczema by affecting how the cells of the immune system work.” There are 136 identified genetic risk factors behind the connection.2

Fortunately, genetics can be influenced based on the understanding of epigenetics. “For example, we found one gene — called PITPNM2 — that is more likely to be switched off in people who smoke… [and] the risk of developing allergies increases,” said Dr Ferreira.2

4. Hypersensitivity

Do you find yourself better at fighting common infections (e.g. cold, flu)?

We know that eczema is more than a skin condition because there’s something wrong with our immune system. In fact, one theory believes that people with eczema suffer from Th1 dominance, which basically means we have too many of one specific group of immune fighter cells which keep our body at bay. We need it, but we just have too much.

What’s fascinating is that the downside of Th1 dominance triggers eczema development and high sensitivity towards food allergies. The upside is that such extra immune alertness we have helps us in fighting common extracellular infections, i.e. outside of our cells.

5. Digestive Unease

Do you experience bloating, constipation, and digestive irregularities?

Leaky gut syndrome is no longer a new term. But perhaps it is simply a term coined to describe the more distant symptoms (e.g. digestive as opposed to topical)? While there is plenty of ground for debate on the evidence of leaky gut syndrome, in my opinion, it is only a matter of time to build up links of evidence.

From personal experience, and eczema patients I have come across, we tend to have digestive issues. Personally, I bloat if I have too much dairy. I don’t have extreme lactose intolerance but I don’t feel well if I overeat dairy. Another issue I used to have was persistent constipation.

As cliche goes, by Hippocrates: “All disease begins in the gut.”

6. Skin Symptom Extensions

Including eczema, do you also experience psoriasis, butterfly rashes, and white purplish lips?

Like the atopic march, which is the jump, or inevitable manifestation, from one condition to another (e.g. from eczema to also asthma), I have also noticed the extension of regular eczema patch locations, to jump around from arm/leg creases, to psoriasis and facial symptoms.

I put this section at the end because this extension hypothesis that I have continues to resurface from time to time, as my level of eczema fluctuates. Most often, white purplish lips (as opposed to healthy reddish lips) accompany my eczema. When I feel worse, my regular patches in arm/leg creases will trigger facial rashes which look like a butterfly rash. When my skin gets really bad, I develop small little psoriasis patches around my body in random locations.

7. “Feeling Heated Up”

Do you feel more irritable, higher in body temperature, and more alert?

Unsure how to describe this feeling I get, but I’ve noticed one thing. From primary to high school, my eczema was highly obvious and problematic in my life. It was not until later in University years I learned to manage down to 10% of symptoms. But this transition meant I lost this fascinating ability: tolerance to the cold temperature.

When I was younger, I never really caught a cold despite wearing fewer clothes than most people in winter. I felt a higher body temperature in general. It might not be literally, but at least the feeling of heat is throughout the body. And accompanying that is a higher level of irritability, and on the upside, alertness. I hypothesize it is due to higher levels of stress due to immune overdrive. Something to do with cortisol and adrenaline in the endocrine system. But for now, I call it “feeling heated up.”

What About You?

Do you identify with any of these? Do you have unique symptoms?
Share with me in the comments below! It’d be interesting to learn what eczema brings.

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

  1. Schram, M.E., Leeflang, M.G., J.P., Den Ottolander, P.I.S., Spuls, P.I., Bos, J.D. (March 2011). Validation and refinement of the Millennium Criteria for atopic dermatitis. Accessed online at
  2. Willis, O. October 30th, 2017. Scientists identify genetic risk factors for asthma, hay fever and eczema.
  3. Are You Th1 or Th2 Dominant? Effects + Immune Response. June 6, 2018. Accessed online at


  • Andrew
    3 months ago

    William R Clark’s book, “At War Within”, will clear up much of the confusion. Pages 89-106.

    These are the pages covering the subject of immunoglobulin IgE. That is the culprit you are seeking.

  • Sarah Wallin moderator
    3 months ago

    @andrew, I will have to check out that book! Thank you for sharing. This article also has a section with some basic information about Immunoglobin E (IgE) and atopic dermatitis: -Sarah ( Team Member)

  • tbschommer
    3 months ago

    I experience 6 of the 7 symptoms.

    Feeling “heated up” extends to sweating profusely when the temperature goes above ~18°C (~64°F) whenever simply going for a walk.

    Also, when going to bed, it often takes 5-10 minutes for me to heat up so much that I push the blanket away. It takes another 10 minutes to for me to just cool down enough to relax again.

  • Sarah Wallin moderator
    3 months ago

    As you can see from the numerous comments – you aren’t alone! It sounds like many others feel heated up, too. That has to be frustrating to deal with when you’re trying to rest. You may find interest in this discussion about getting sleep when sweat is a main trigger: Take care, Sarah ( Team Member)

  • bzmomwith5
    9 months ago

    Definitely can relate! As an adolescent my skin was a constant flare up. I’d have such horrible scabs behind knees that I couldn’t bend them. That list yes 6 of 7 haven’t had the eyebrow thing. I dread summer! Or any temp above 60-65 really and humidity! One interesting thing though the only time my skin was absolutely perfect and flare up free… Was when I was pregnant. I’d be interested in finding out if anyone else experienced this at all. Plus I’ve never really had a huge problem with acne.

  • Sarah Wallin moderator
    9 months ago

    Hi @bzmomwith5, I’m glad you can relate! It sounds like you have experience with many of these symptoms. That’s interesting that your skin cleared up during pregnancy! We often hear mixed reviews about eczema during pregnancy (some people say their skin got better, some say it got worse). If you want to start a forum about it, you may hear from others who have experienced the same. You can do that here ( Scroll down to where it says “Start a New Topic” and type away. It would be really interesting to see what others say! In the meantime, here is an article about hormones and AD which you might be interested in ( Take care, Sarah ( Team Member)

  • Loretta
    9 months ago

    The butterfly facial rash and lip discoloration you discuss are symptoms of lupus. Another step on the auto-immune march.

  • Sarah Wallin moderator
    9 months ago

    Great point, @loretta. Do you have personal experience with lupus? We encourage anyone who does experience a butterfly facial rash, in addition to fatigue and other common symptoms of lupus ( to seek attention from their doctor. -Sarah ( Team Member)

  • Ashley Ann Lora moderator
    2 years ago

    Thank you for this information! I can relate to 5 out of the 7 mentioned. This includes #7 and the feeling of “heating” up. Growing up and all the way into college, I was the girl who had the AC on in addition to 2 fans blowing on me at all time haha. Can any of you relate to this?

  • Zsuzsa
    2 years ago

    This article was amazing! It validates my experiences. In childhood, I didn’thave excema but I did have food allergies. Just the opposite, now. My rosacea began in pregnancy. Eyebrow thinningwith normal thyroid. All the extensions.
    Now that I’m in chemotherapy, the excema appears
    to be subsiding. Will it come back afterthe chemo is done? Can I prepare for itsomehow?

  • Ashley Ann Lora moderator
    2 years ago

    Hi Zsuzsa,

    Thank you for sharing your story.

    I would recommend you ask your doctor if there’s a correlation between chemotherapy and eczema and the possibility of you reacting to the chemotherapy.

    This may be a good start 🙂

    Let us know what your doctor says!


  • Harrison Li author
    2 years ago

    Hi Zsuzsa,

    I’m glad that you found the symptoms relatable, and yet sad that these things just never really go away and affect us across all stages of eczema life.

    Is your chemotherapy for eczema? If you don’t mind me asking. I’ve never known anyone who is doing it for eczema… wondering how that works out…

  • jvcxtwo
    2 years ago

    Oh my- half brows, panda eyes and more. Yes to 6 of 7

  • Ashley Ann Lora moderator
    2 years ago

    Hi jvcxtwo – my cousin suffers from the panda eyes too. What do you use/do to manage it?

  • Sarah Wallin moderator
    2 years ago

    jvcxtwo – sounds like you can relate to a bunch of the symptoms in this article, and I know there are others who can relate too. Any advice for how you manage? -Sarah ( Team Member)

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