What Is Adbry™ (tralokinumab-ldrm)?

Reviewed by: HU Medical Review Board | Last reviewed: June 2022 | Last updated: August 2022

Adbry™ (tralokinumab-ldrm) is a prescription drug for moderate to severe atopic dermatitis (eczema).1

Adbry is for adults with atopic dermatitis who cannot use topical treatment. It is also for adults whose atopic dermatitis is not well controlled with topical therapy. The injectable drug can be used with or without topical steroids.1

Adbry is a type of biologic drug called an interleukin-13 antagonist. It is the first IL-13 antagonist biologic drug approved by the U.S. Food and Drug Administration (FDA) to treat atopic dermatitis.1,2

What are the ingredients in Adbry?

The active ingredient in Adbry is tralokinumab-ldrm.1

How does Adbry work?

The active ingredient in Adbry, tralokinumab, is a human monoclonal antibody. These are drugs designed to attach to a certain protein in your cells. Tralokinumab works by attaching to the IL-13 protein.1,2

The IL-13 protein plays a big role in the immune and inflammatory processes that lead to the symptoms of atopic dermatitis. Adbry binds to the IL-13 cytokine and blocks interaction with the IL-13 receptor to stop the inflammatory process.1,2

What are the possible side effects of Adbry?

The most common side effects of Adbry include:1

  • Eye and eyelid inflammation, redness, swelling, and itching
  • Injection site reactions
  • Eosinophilia (high eosinophil count, a type of white blood cell)
  • Upper respiratory tract infections

Adbry can also cause serious side effects, including:1

  • Allergic reactions and hypersensitivity
  • Anaphylaxis, a severe allergic reaction
  • Eye problems, including eye pain and changes in vision

These are not all the possible side effects of Adbry. Talk to your doctor about what to expect when taking Adbry. You also should call your doctor if you have any changes that concern you when taking Adbry.

Things to know about Adbry

Adbry is an injectable drug. It comes in a single-dose, prefilled syringe. Adbry should be used under guidance of a doctor. It can be self-injected or injected at home after proper training.1

Increased risks

Adbry may increase the risk of infection or alter immunity after getting certain vaccines. Before starting Adbry, ask your doctor if you need to receive any vaccines.1

As with all therapeutic proteins, there is a risk for an immune response to Adbry, which lowers effectiveness over time. This is known as immunogenicity.3

Who can and can not use the drug?

People who have known hypersensitivity to tralokinumab-ldrm or any of Adbry’s inactive ingredients should not use the drug.1

People with parasitic worms should be treated before starting Adbry. It is unknown if Adbry will affect the body’s immune response against parasitic worms.1

There is not enough information to know if Adbry is safe to take while pregnant or breastfeeding. Talk to your doctor about your options for birth control and breastfeeding before taking Adbry.1

Other treatments

Adbry can be used with or without topical steroids. Topical calcineurin inhibitors (TCIs) can be used, but only in problem areas.1

Before beginning treatment for atopic dermatitis, tell your doctor about all of your health conditions and any other drugs, vitamins, or supplements you take. This includes over-the-counter drugs.

For more information, read the full prescribing information of Adbry.

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